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Symbol Name ID |
Chrna4
cholinergic receptor, nicotinic, alpha polypeptide 4 MGI:87888 |
| * | Aspects of the system are reported to show a normal phenotype. |
| Darker colors indicate more annotations |
| Human Phenotypes | Intellectual disability |
Seizure |
Focal-onset seizure |
| Disease(s) Associated with CHRNA4 | |||
| autosomal dominant nocturnal frontal lobe epilepsy 1 |
| Mouse Phenotypes | nervous system phenotype |
increased susceptibility to pharmacologically induced seizures |
seizures |
clonic seizures |
abnormal brain morphology |
decreased dopaminergic neuron number |
abnormal nervous system physiology |
abnormal brain wave pattern |
abnormal inhibitory postsynaptic currents |
abnormal nicotine-mediated receptor currents |
abnormal synaptic dopamine release |
decreased neurotransmitter release |
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| Availability | Mouse Genotype | ||||||||||||
| Chrna4tm1.2Tmcg/Chrna4tm1.2Tmcg | |||||||||||||
| Chrna4tm1Dra/Chrna4tm1Dra | |||||||||||||
| Chrna4tm1Jbou/Chrna4tm1Jbou | |||||||||||||
| Chrna4tm1Jpc/Chrna4tm1Jpc | * | ||||||||||||
| Chrna4tm1Lst/Chrna4tm1Lst | |||||||||||||
| Chrna4tm2Jbou/Chrna4tm2Jbou | |||||||||||||
| Chrna4tm1Jbou/Chrna4+ | |||||||||||||
| Chrna4tm2Jbou/Chrna4+ | |||||||||||||
| Chrna4tm1.1Tmcg/Chrna4tm1.1Tmcg Slc6a3tm1(cre)Xz/Slc6a3+ (conditional) |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/23/2024 MGI 6.23 |
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